Real SAM-e Reviews From Real People. By now, almost everyone has heard about SAM-e or S-Adenosyl methionine, it seems not a day goes by without another news story about this “miracle supplement” popping up somewhere. Some of the claims being made about SAM-e are truly extraordinary, and news about it’s remarkable effectiveness as a treatment for depression and arthritis seems to be everywhere. All of this can be confusing if you are considering adding SAM-e to your supplement regimen, and you are likely to have a number of questions about SAM-e’s benefits, side effects, dosages and interactions that can only be answered by your doctor. The one thing your doctor might not be able to tell you about is the experiences others have had with SAM-e. On this site, we’ve compiled some SAM-e reviews from real people in order to gauge it’s effectiveness in treating depression, memory loss, arthritis, and liver disease. We hope that this information can help you to make an informed decision about whether SAM-e is right for you.